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ergotamine will boost the amount or effect of avapritinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Watch.
Stay away from or substitute Yet another drug for these remedies when possible. Consider for lack of therapeutic impact if medication should be coadministered. Modify dose Based on prescribing information and facts if desired.
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Take into consideration reducing the dose of your delicate CYP3A4 substrate and keep an eye on for indications click here of toxicities from the coadministered sensitive CYP3A substrate.
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On initiation or discontinuation of ustekinumab in patients that are acquiring concomitant CYP450 substrates, notably those by using a slim therapeutic index, take into consideration monitoring for therapeutic impact.
ergotamine decreases consequences of glyceryl trinitrate pr by pharmacodynamic antagonism. Contraindicated.
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viloxazine will enhance the stage or outcome of ergotamine by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Viloxazine (a weak CYP3A4 inhibitor) may possibly maximize systemic exposure of delicate CYP3A4 substrates. Monitor and regulate dose of substrate as clinically indicated.
conivaptan will boost the level or effect of ergotamine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated.